SPRB · Current Report (Form 8-K) · Filed February 5, 2026

Spruce Biosciences Inc — 8-K exhibit

sprb-ex99_2.htm

Spruce Biosciences Inc on Boardroom Alpha

TA Stabilizes Communication in VABS-II in MPS IIIB Observational Study 902 and TA Treatment Study 201+EXT VABS Overall AEq VABS Receptive Communication Raw Score VABS Expressive Communication Raw Score AEq=age equivalent; MPS IIIB=mucopolysaccharidosis type IIIB; TA=tralesinidase alfa; VABS=Vineland Adaptive Behavior Scales, Second Edition. Sources: : Integrated Table 5.3.5.3.1-2.3.1.5.1; Integrated Table 5.3.5.3.1-2.3.1.5.3; Integrated Table 5.3.5.3.1-2.3.1.5.4; Integrated Table 5.3.5.3.1-2.3.1.5.5

TA Stabilizes and Preserves Motor Skills in MPS IIIBObservational Study 902 and TA Interventional Studies 201+EXT Mean ± SE of Vineland Adaptive Behavior Scales, 2nd Edition Over Age Groups VABS Fine Motor Raw Score VABS Gross Motor Raw Score AEq=age equivalent; MPS IIIB=mucopolysaccharidosis type IIIB; TA=tralesinidase alfa; VABS=Vineland Adaptive Behavior Scales, Second Edition. Sources: : Integrated Table 5.3.5.3.1-2.3.1.5.14; Integrated Table 5.3.5.3.1-2.3.1.5.15

Disclaimer

The opinions and information contained herein have been obtained or derived from sources believed to be reliable, but Boardroom Alpha cannot guarantee its accuracy and completeness, and that of the opinions based thereon.

This report contains opinions and is provided for informational purposes only – it does not constitute investment, legal or tax advice. You should not rely solely upon the research herein for purposes of transacting securities or other investments, and you are encouraged to conduct your own research and due diligence, and to seek the advice of a qualified securities professional before you make any investment.

None of the information contained in this report constitutes, or is intended to constitute a recommendation by Boardroom Alpha of any particular security or trading strategy or a determination by Boardroom Alpha that any security or trading strategy is suitable for any specific person. To the extent any of the information contained herein may be deemed to be investment advice, such information is impersonal and not tailored to the investment needs of any specific person.

No representation or warranty, expressed or implied, is made on behalf of Boardroom Alpha as to the accuracy or completeness of the information contained herein. Boardroom Alpha does not accept any liability for any direct, indirect or consequential loss or damage suffered by any person as a result of relying on all or any part of this research and any liability is expressly disclaimed.

Full disclaimer