Exhibit 10.22.1
LONGEVERON INC.
AMENDMENT NO. 1 TO AT THE MARKET OFFERING AGREEMENT
June 16, 2026
H.C. Wainwright & Co., LLC
430 Park Avenue
New York, NY 10022 Ladies and Gentlemen:
Reference is made to the At the Market Offering Agreement, dated September 19, 2025 (the “Sales Agreement”), by and between Longeveron Inc., a Delaware corporation (the “Company”), and H.C. Wainwright & Co., LLC (the “Manager”). Capitalized terms used herein but not otherwise defined are used herein as defined in the Sales Agreement.
The Company and the Manager (collectively, the “Parties”) wish to amend the Agreement, to be effective as of the date hereof, pursuant to Section 14 of the Sales Agreement, on the terms and conditions set forth in this letter (this “Amendment”). Therefore, for and in consideration of the mutual covenants and agreements herein contained, and contained in the Sales Agreement, the Company, on the one hand, and the Manager, on the other hand, the Parties therefore hereby agree as follows:
“Except as set forth in the SEC Reports, the Company has not been informed by the FDA that the FDA will prohibit the marketing, sale, license or use in the United States of any product proposed to be developed, produced or marketed by the Company. Except as set forth in the SEC Reports, the FDA has not expressed any concern in writing as to approving or clearing for marketing any product being developed or proposed to be developed by the Company, except as would not, individually or in the aggregate, reasonably be expected to result in a Material Adverse Effect.”
(Signature page follows.)
Exhibit 10.22.1
If the foregoing is in accordance with your understanding of our agreement, please sign and return to the Company a counterpart hereof; whereupon this instrument, along with all counterparts, will become a binding agreement by the Company and the Manager in accordance with its terms.
Very trulyyours, |
LONGEVERON INC. |
By: |
Name: Stephen H. Willard |
Title: Chief Executive Officer |
The foregoing Amendment No. 1 to the Sales Agreement is hereby confirmed and accepted as of the datefirst written above. |
H.C. WAINWRIGHT & CO., LLC |
By: /s/ Merav Gershtenman |
Name: Merav Gershtenman Title: Chief Legal Officer |
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