ENTA · Annual Report (Form 10-K) · Filed November 19, 2025

Enanta Pharmaceuticals Inc — 10-K exhibit

enta-ex32_1.htm

Enanta Pharmaceuticals Inc on Boardroom Alpha

EX-32.1

Exhibit 32.1

Certification of Periodic Financial Report

Pursuant to 18 U.S.C. Section 1350

as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Each of the undersigned officers of Enanta Pharmaceuticals, Inc. (the “Company”) certifies, to his knowledge and solely for the purposes of 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that the Annual Report on Form 10-K of the Company for the year ended September 30, 2025 complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 and that information contained in the Form 10-K fairly presents, in all material respects, the financial condition and results of operations of Enanta.

Dated: November 19, 2025

/s/ Jay R. Luly, Ph.D.

Jay R. Luly, Ph.D.

President and Chief Executive Officer

(Principal Executive Officer)

Dated: November 19, 2025

/s/ Harry R. Trout III

Harry R. Trout III

Vice President, Finance

(Principal Financial Officer)

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