Exhibit 10.2

SECOND AMENDMENT TO LEASE
This Second Amendment to Lease (the “Second Amendment”) is entered into and effective as of December 9, 2025 (the “Effective Date”) by and between CROSSING HOLDINGS, LLC, a California limited liability company (“Landlord”) and DESIGN THERAPEUTICS, INC, a Delaware corporation (“Tenant”) (Landlord and Tenant are from time to time referred to herein each as a “Party” and collectively as the “Parties”).
RECITALS
AGREEMENT
NOW THEREFORE, based on the foregoing recitals, the truth and accuracy of which are hereby confirmed by the parties, and for and in consideration of the mutual promises and covenants hereinafter set forth, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:
(a) Commencing on the later of (i) January 1, 2026 or (ii) the Closing Date as defined below (the “Base Rent Commencement Date”), the annual Base Rent for the Premises shall be as set forth in the following Schedule:
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Base Rent Schedule
Period |
Annual Base Rent/SF | Monthly Base Rent/SF | Total Monthly Base Rent |
Total Annual Base Rent |
Base Rent Commencement Date- 12/31/2026 |
$50.00 |
$4.167 |
$72,625 |
$871,500 |
01/01/2027-12/31/2027 |
$51.50 |
$4.292 |
$74,804 |
$897,645 |
01/01/2028-12/31/2028 | $53.05 | $4.420 | $77,048 | $924,574 |
01/01/2029-12/31/2029 | $54.64 | $4.553 | $79,357 | $952,289 |
Provided, however, for the first four (4) months from the Base Rent Commencement Date, Tenant shall pay one-half the monthly Base Rent. Beginning on the fifth (5th) month after the Base Rent Commencement Date, Tenant shall pay the full monthly Base Rent pursuant to the above schedule. No Operating Expense Rent or Tax Rent shall be abated during the first four (4) months after the Base Rent Commencement Date and Tenant’s Share as set forth in subsection (b) below shall continue to be paid in full pursuant to the terms of the Lease.
For clarification purposes, the Parties acknowledge that pursuant to the First Amendment, Tenant leased from Landlord additional Expansion Premises. The rent for the Original Premises under the Original Lease was different than the rent set for the Expansion Premises under the First Amendment; provided, however, the First Amendment defined Base Rent as the collective rent of the Base Rent for the Original Premises and the Base Rent for the Expansion Premises. Commencing on the Base Rent Commencement Date, the Base Rent shall be for the Premises (i.e. Suites 110, 115, 150, and 210, which are the Original Premises and the Expansion Premises combined). The Original Premises and the Expansion Premises shall no longer have separate rental rates and the rent for the Premises as a whole shall be as set forth on the schedule above.
As further clarification, Tenant shall continue to pay Base Rent pursuant to the current terms of the Lease until the Base Rent Commencement Date. Subject to the condition precedent set forth in Section 6 herein below, upon the Base Rent Commencement Date, the Base Rent shall be paid pursuant to the schedule set forth above.
(b) The Parties acknowledge and agree that Tenant’s Share as defined in Paragraph L of the Basic Lease Provisions of the Original Lease shall be 24.105%, which Tenant’s Share shall apply to Tenant’s payment of Operating Expense Rent, Tax Rent, and as otherwise set forth in the Lease.
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and conditions as set forth in the Lease, except as specifically modified by this Second Amendment. During the extension term, the Base Rent shall be increased annually in a manner consistent with the Base Rent Schedule set forth herein above in Section 3 of this Second Amendment, which is an increase of Base Rent by three percent (3%) per rentable square foot over the Base Rent for the prior Lease Year.
Landlord hereby represents and warrants to Tenant based on Landlord's actual knowledge that, as of the date of this Second Amendment: (a) Tenant is in full compliance with all terms, covenants and conditions of the Lease; (b) Tenant is not in breach or default under the Lease, nor has any event occurred, which, with the passage of time or the giving of notice, or both, would constitute a breach or default by Tenant; (c) no actions, whether voluntary or otherwise, are pending against Landlord under the bankruptcy laws of the United States or any state thereof; and (e) the Lease, as amended, constitutes the complete agreement of Landlord and Tenant with respect to the Premises, and there are no other amendments, oral or written, to the Lease.
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dealings with any real estate broker, agent, or finder in connection with the negotiation of this Second Amendment, and that they know of no other real estate broker, agent, or finder who is entitled to a commission or finder's fee in connection with this Second Amendment. Any commission or fee shall be paid to Broker pursuant to the terms of a separate agreement. Each party shall indemnify, protect, defend, and hold harmless the other party against all claims, demands, losses, liabilities, lawsuits, judgments, and costs and expenses (including reasonable attorney fees) for any leasing commission, finder’s fee, or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any real estate broker, agent, or finder. The terms of this Section will survive the expiration of the Term.
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IN WITNESS WHEREOF, Landlord and Tenant have executed this Second Amendment to Lease as of the Effective Date first set forth above.
TENANT |
| LANDLORD | ||
DESIGN THERAPEUTICS, INC., |
| CROSSING HOLDINGS, LLC, | ||
a Delaware corporation |
| a California limited liability company | ||
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By: | /s/ Mustapha Parekh |
| By: | /s/ John C. Stancil |
Name: | Mustapha Parekh |
| Name | John C. Stancil |
Title: | General Counsel |
| Title: | Manager |
Date: | December 9, 2025 |
| Date: | December 10, 2025 |
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