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Exhibit 21
Exhibit 21 – Subsidiaries of the Registrant
Listed below are subsidiaries of The Cigna Group as of December 31, 2025 with their jurisdictions of organization. Those subsidiaries not listed would not, in the aggregate, constitute a “significant subsidiary” of The Cigna Group, as that term is defined in Rule 1-02(w) of Regulation S-X.
| 2025 Subsidiaries Or Affiliates | Jurisdiction | ||||
| Accredo Health, Incorporated | Delaware | ||||
| Allegiance Life & Health Insurance Company | Montana | ||||
| Care Alliance of Florida, LLC | Florida | ||||
| Care Continuum, Inc. | Kentucky | ||||
| CareCore NJ, LLC | New Jersey | ||||
| Chiro Alliance Corporation | Florida | ||||
| Cigna & CMB Life Insurance Company Limited | China | ||||
| Cigna Arbor Life Insurance Company | Connecticut | ||||
| Cigna Dental Health Of California, Inc. | California | ||||
| Cigna Dental Health Of Colorado, Inc. | Colorado | ||||
| Cigna Dental Health Of Delaware, Inc. | Delaware | ||||
| Cigna Dental Health Of Florida, Inc. | Florida | ||||
| Cigna Dental Health Of Kansas, Inc. | Kansas | ||||
| Cigna Dental Health Of Kentucky, Inc. | Kentucky | ||||
| Cigna Dental Health Of Maryland, Inc. | Maryland | ||||
| Cigna Dental Health Of Missouri, Inc. | Missouri | ||||
| Cigna Dental Health Of New Jersey, Inc. | New Jersey | ||||
| Cigna Dental Health Of North Carolina, Inc. | North Carolina | ||||
| Cigna Dental Health Of Ohio, Inc. | Ohio | ||||
| Cigna Dental Health Of Pennsylvania, Inc. | Pennsylvania | ||||
| Cigna Dental Health Of Texas, Inc. | Texas | ||||
| Cigna Dental Health Of Virginia, Inc. | Virginia | ||||
| Cigna Dental Health Plan Of Arizona, Inc. | Arizona | ||||
| Cigna Europe Insurance Company S.A.-N.V. | Belgium | ||||
| Cigna Global Insurance Company Limited | Guernsey | ||||
| Cigna Global Reinsurance Company, Ltd. | Bermuda | ||||
| Cigna Health and Life Insurance Company | Connecticut | ||||
| Cigna HealthCare of Arizona, Inc. | Arizona | ||||
| Cigna HealthCare of California, Inc. | California | ||||
| Cigna HealthCare of Connecticut, Inc. | Connecticut | ||||
| Cigna HealthCare of Florida, Inc. | Florida | ||||
| Cigna HealthCare of Georgia, Inc. | Georgia | ||||
| Cigna HealthCare of Illinois, Inc. | Illinois | ||||
| Cigna HealthCare of Indiana, Inc. | Indiana | ||||
| Cigna HealthCare of New Hampshire, Inc. | New Hampshire | ||||
| Cigna HealthCare of New Jersey, Inc. | New Jersey | ||||
| Cigna HealthCare of North Carolina, Inc. | North Carolina | ||||
| Cigna HealthCare of South Carolina, Inc. | South Carolina | ||||
| Cigna HealthCare of St. Louis, Inc. | Missouri | ||||
| Cigna HealthCare of Tennessee, Inc. | Tennessee | ||||
| Cigna HealthCare of Texas, Inc. | Texas | ||||
| Cigna Holding Company | Delaware | ||||
| Cigna Holdings, Inc. | Delaware | ||||
| Cigna Insurance Middle East S.A.L. | Lebanon | ||||
| Cigna Life Insurance Company of Canada | Canada | ||||
| Cigna Life Insurance Company of Europe S.A.-N.V. | Belgium | ||||
| Cigna Services Middle East FZE | Dubai | ||||
| Cigna Worldwide General Insurance Company Limited | Hong Kong | ||||
| Cigna Worldwide Insurance Company | Delaware | ||||
| Cigna-Evernorth Enterprise Services, Inc. | Delaware | ||||
| Connecticut General Corporation | Connecticut | ||||
| Connecticut General Life Insurance Company | Connecticut | ||||
| CPRx MSO, LLC | Delaware | ||||
| Evernorth Accountable Care, LLC | Delaware | ||||
| Evernorth Health, Inc. | Delaware | ||||
| Evernorth Wholesale Distribution, Inc. | Delaware | ||||
| Evernorth-VillageMD Care Alliance of NJ, LLC (F/K/A "ENAC of NJ, LLC") | New Jersey | ||||
| eviCore Healthcare MSI, LLC | Tennessee | ||||
| Express Scripts Administrators LLC | Delaware | ||||
| Express Scripts Utilization Management Company | Delaware | ||||
| Express Scripts, Inc. | Delaware | ||||
| Inside RX, LLC | Delaware | ||||
| ManipalCigna Health Insurance Company Limited | India | ||||
| Matrix Healthcare Services, Inc. | Florida | ||||
| Medco Health Solutions, Inc. | Delaware | ||||
| MSI Health Organization of Texas, Inc. | Texas | ||||
| Pipeline Health Holdings LLC | Delaware | ||||
| Prohealth Pharmacy Solutions, LLC | Florida | ||||
| Temple Insurance Company Limited | Bermuda | ||||