SECURITIES AND EXCHANGE COMMISSION
Securities Exchange Act of 1934
(Amendment No. )
18 Campus Boulevard Suite, 100
Newtown Square, PA 19073
| | | | | Sincerely, | |
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| | | | | Zhengbin (Bing) Yao, Ph.D. Chairman, President and Chief Executive Officer | |
18 Campus Boulevard, Suite 100
Newtown Square, PA 19073
DATE: June 18, 2026
VIRTUALLY AT: www.virtualshareholdermeeting.com/AVBP2026
| | | | | BY ORDER OF THE BOARD OF DIRECTORS | |
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| | | | | James Kastenmayer Secretary and General Counsel | |
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18 CAMPUS BOULEVARD, SUITE 100
NEWTOWN SQUARE, PA 19073
2026 ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 18, 2026
THE STOCKHOLDER MEETING TO BE HELD ON JUNE 18, 2026
| | Proposal 1: Elect Director | | | The nominees for director who receive the most votes (also known as a “plurality” of the votes cast) will be elected. You may vote either FOR the nominees or WITHHOLD your vote from the nominees. Votes that are withheld will not be included in the vote tally for the election of the director. Brokerage firms do not have authority to vote customers’ unvoted shares held by the firms in street name for the election of the directors. As a result, any shares not voted by a customer will be treated as a broker non-vote. Such broker non-votes will have no effect on the results of this vote. | |
| | Proposal 2: Ratify Appointment of Independent Registered Public Accounting Firm | | | The affirmative vote of a majority of the shares cast affirmatively or negatively for this proposal is required to ratify the appointment of our independent registered public accounting firm. Abstentions will have no effect on the results of this vote. Brokerage firms have authority to vote customers’ unvoted shares held by the firms in street name on this proposal. If a broker does not exercise this authority, such broker non-votes will have no effect on the results of this vote. We are not required to obtain the approval of our stockholders to appoint our independent registered public accounting firm. However, if our stockholders do not ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for 2026, our audit committee of our board of directors will reconsider its selection. | |
| | | | Shares Beneficially Owned | | |||||||||
| Name and Address(1) | | | Number | | | Percent | | ||||||
| Greater than 5% Stockholders: | | | | | | | | | | | | | |
| Entities affiliated with Infinitum Asset Management, LLC(2) | | | | | 4,123,923 | | | | | | 8.89% | | |
| Entities affiliated with Hillhouse Investment Management, Ltd.(3) | | | | | 3,929,117 | | | | | | 8.47% | | |
| Entities affiliated with Suvretta Capital Management, LLC(4) | | | | | 3,412,788 | | | | | | 7.36% | | |
| FMR LLC(5) | | | | | 3,407,549 | | | | | | 7.35% | | |
| Entities affiliated with OrbiMed(6) | | | | | 3,027,328 | | | | | | 6.53% | | |
| Entities affiliated with BlackRock, Inc.(7) | | | | | 2,319,341 | | | | | | 5.00% | | |
| Named Executive Officers and Directors: | | | | | | | | | | | | | |
| Zhengbin (Bing) Yao, Ph.D.(8) | | | | | 1,367,875 | | | | | | 2.90% | | |
| Winston Kung, MBA(9) | | | | | 159,167 | | | | | | * | | |
| Stuart Lutzker, M.D., Ph.D.(10) | | | | | 386,617 | | | | | | * | | |
| James Healy, M.D., Ph.D.(11) | | | | | 1,696,752 | | | | | | 3.66% | | |
| John Hohneker, M.D.(12) | | | | | 35,202 | | | | | | * | | |
| Chris W. Nolet(13) | | | | | 44,344 | | | | | | * | | |
| Kristine Peterson(14) | | | | | 34,560 | | | | | | * | | |
| Merdad Parsey, M.D., Ph.D.(15) | | | | | 9,449 | | | | | | * | | |
| All current executive officers and directors as a group (10 persons)(16) | | | | | 4,105,613 | | | | | | 8.58% | | |
| Name | | | Age | | | Position | |
| Zhengbin (Bing) Yao, Ph.D. | | | 60 | | | Chief Executive Officer and Chairman of Board | |
| Stuart Lutzker, M.D., Ph.D. | | | 65 | | | President, Research and Development and Director | |
| James Healy, M.D., Ph.D.(1)(3) | | | 61 | | | Director | |
| John Hohneker, M.D.(2)(3) | | | 66 | | | Director | |
| Chris W. Nolet(1)(3) | | | 69 | | | Director | |
| Merdad Parsey, M.D., Ph.D.(2) | | | 63 | | | Director | |
| Kristine Peterson(1)(2) | | | 66 | | | Lead Independent Director | |
| Name | | | Age | | | Position | |
| Winston Kung, MBA | | | 50 | | | Chief Financial Officer and Treasurer | |
| Robin LaChapelle | | | 53 | | | Chief Operating Officer | |
| James Kastenmayer, J.D., Ph.D. | | | 54 | | | General Counsel and Secretary | |
| Name and Principal Position | | | Year | | | Salary ($)(1) | | | Option Awards ($)(2) | | | Non-Equity Incentive Plan Compensation ($)(3) | | | All Other Compensation ($)(4) | | | Total ($) | | ||||||||||||||||||
| Zhengbin (Bing) Yao, Ph.D | | | | | 2025 | | | | | | 596,667 | | | | | | 8,405,486 | | | | | | 358,000 | | | | | | 14,000 | | | | | | 9,374,153 | | |
| Chief Executive Officer and President | | | | | 2024 | | | | | | 558,183 | | | | | | 1,596,043 | | | | | | 238,623 | | | | | | 13,800 | | | | | | 2,406,649 | | |
| Stuart Lutzker, M.D., Ph.D | | | | | 2025 | | | | | | 515,779 | | | | | | 2,654,364 | | | | | | 247,574 | | | | | | 14,000 | | | | | | 3,431,717 | | |
| President, Research and Development | | | | | 2024 | | | | | | 495,941 | | | | | | 297,457 | | | | | | 179,035 | | | | | | 13,534 | | | | | | 985,967 | | |
| Winston Kung, MBA | | | | | 2025 | | | | | | 492,417 | | | | | | 2,654,364 | | | | | | 246,287 | | | | | | 14,000 | | | | | | 3,407,068 | | |
| Chief Financial Officer and Treasurer | | | | | 2024 | | | | | | 469,602 | | | | | | 1,190,331 | | | | | | 158,840 | | | | | | 13,800 | | | | | | 1,832,573 | | |
| | | | Option Awards(1)(2) | | |||||||||||||||||||||||||||
| Name | | | Option Grant Date | | | Number of Securities Underlying Unexercised Options (#) Exercisable | | | Number of Securities Underlying Unexercised Options (#) Unexercisable | | | Option Exercise Price ($) | | | Option Expiration Date | | |||||||||||||||
| Zhengbin (Bing) Yao, Ph.D | | | | | 9/8/2021 | | | | | | 105,193 | | | | | | — | | | | | $ | 2.28 | | | | | | 9/7/2031 | | |
| | | | | | 2/1/2022 | | | | | | 235,014 | | | | | | 10,217 | | | | | $ | 2.28 | | | | | | 1/31/2032 | | |
| | | | | | 2/1/2023 | | | | | | 100,129 | | | | | | 41,224 | | | | | $ | 3.65 | | | | | | 1/31/2033 | | |
| | | | | | 1/1/2024 | | | | | | 126,776 | | | | | | 137,798 | | | | | $ | 7.76 | | | | | | 12/31/2033 | | |
| | | | | | 2/3/2025 | | | | | | — | | | | | | 380,000 | | | | | $ | 27.56 | | | | | | 2/2/2035 | | |
| Stuart Lutzker, M.D., Ph.D | | | | | 9/8/2021 | | | | | | 65,746 | | | | | | — | | | | | $ | 2.28 | | | | | | 9/7/2031 | | |
| | | | | | 2/1/2022 | | | | | | 64,897 | | | | | | 2,820 | | | | | $ | 2.28 | | | | | | 1/31/2032 | | |
| | | | | | 2/1/2023 | | | | | | 30,274 | | | | | | 12,460 | | | | | $ | 3.65 | | | | | | 1/31/2033 | | |
| | | | | | 1/1/2024 | | | | | | 23,629 | | | | | | 25,680 | | | | | $ | 7.76 | | | | | | 12/31/2033 | | |
| | | | | | 2/3/2025 | | | | | | — | | | | | | 120,000 | | | | | $ | 27.56 | | | | | | 2/2/2035 | | |
| Winston Kung, MBA | | | | | 1/4/2024 | | | | | | 94,512 | | | | | | 102,726 | | | | | | 7.76 | | | | | | 1/3/2034 | | |
| | | | | | 2/3/2025 | | | | | | — | | | | | | 120,000 | | | | | | 27.56 | | | | | | 2/2/2035 | | |
| Name | | | Fees Earned or Paid in Cash ($) | | | Option Awards ($)(1) | | | Total ($) | | |||||||||
| Carl L. Gordon, Ph.D., CFA(2) | | | | | — | | | | | | — | | | | | | — | | |
| James Healy, M.D., Ph.D. | | | | | — | | | | | | — | | | | | | — | | |
| John Hohneker, M.D. | | | | | 58,125 | | | | | | 298,026 | | | | | | 505,006 | | |
| Chris W. Nolet | | | | | 68,750 | | | | | | 298,026 | | | | | | 343,525 | | |
| Kristine Peterson | | | | | 86,250 | | | | | | 298,026 | | | | | | 395,820 | | |
| Merdad Parsey, M.D., Ph.D.(3) | | | | | 39,375 | | | | | | 469,744 | | | | | | 509,119 | | |
| Position | | | Retainer | | |||
| Board Member | | | | $ | 45,000 | | |
| Lead Independent Director | | | | $ | 30,000 | | |
| Audit Committee Chair | | | | $ | 20,000 | | |
| Audit Committee Member | | | | $ | 10,000 | | |
| Compensation Committee Chair | | | | $ | 15,000 | | |
| Compensation Committee Member | | | | $ | 7,500 | | |
| Nominating and Corporate Governance Committee Chair | | | | $ | 10,000 | | |
| Nominating and Corporate Governance Committee Member | | | | $ | 5,000 | | |
| | | | (a) | | | (b) | | | (c) | | |||||||||
| Plan category | | | Number of securities to be issued upon exercise of outstanding options, warrants and rights(1) | | | Weighted- average exercise price of outstanding options, warrants and rights | | | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a))(2) | | |||||||||
| Equity compensation plans approved by security holders | | | | | 4,328,880 | | | | | $ | 15.56 | | | | | | 3,504,507 | | |
| Equity compensation plans not approved by security holders | | | | | — | | | | | | — | | | | | | — | | |
| Total | | | | | 4,328,880 | | | | | $ | 15.56 | | | | | | 3,504,507 | | |
Chris W. Nolet
James Healy, M.D., Ph.D.
Kristine Peterson
| | | | Shares | | | Aggregate Purchase Price | | ||||||
| LAV Fund VI, L.P. | | | | | 100,000 | | | | | $ | 1,800,000 | | |
| Entities affiliated with Octagon Capital Advisors LP | | | | | 200,000 | | | | | | 3,600,000 | | |
| Entities affiliated with OrbiMed | | | | | 444,444 | | | | | | 7,999,992 | | |
| Sofinnova Venture Partners XI, L.P. | | | | | 444,444 | | | | | | 7,999,992 | | |
| Entities affiliated with Hillhouse Investment Management, Ltd | | | | | 555,555 | | | | | $ | 9,999,990 | | |
| | | | Shares or Pre-Funded Warrants | | | Aggregate Purchase Price | | ||||||
| Entities affiliated with Suvretta Capital Management, LLC | | | | | 1,538,461 | | | | | $ | 29,999,990 | | |
| FMR LLC | | | | | 1,025,700 | | | | | | 20,001,150 | | |
ACCOUNTING FIRM
| | | | 2025 | | |||
| Audit Fees(1) | | | | $ | 735,000 | | |
| Audit-Related Fees(2) | | | | | — | | |
| Tax Fees(3) | | | | | — | | |
| All Other Fees(4) | | | | | 2,120 | | |
| Total | | | | $ | 737,120 | | |
| | | | 2025 | | | 2024 | | ||||||
| Audit Fees(1) | | | | $ | 546,558 | | | | | $ | 1,180,295 | | |
| Audit-Related Fees(2) | | | | | — | | | | | | — | | |
| Tax Fees(3) | | | | | — | | | | | | — | | |
| All Other Fees(4) | | | | | — | | | | | | — | | |
| Total | | | | $ | 546,558 | | | | | $ | 1,180,295 | | |
April 28, 2026