Independent
Tenure on this board
1.8 yrs
Also a director at
Crispr Therapeutics AG (CRSP)Sionna Therapeutics Inc (SION)
Meeting calendar
UPB · Annual meeting · Tuesday, June 9, 2026
Upstream Bio Inc
2 nominees · 2 ballot items.
Elect two Class II directors (H. Edward Fleming, Jr., M.D. and Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.) to three-year terms and ratify the appointment of PricewaterhouseCoopers LLP as the company’s independent registered public accounting firm for the fiscal year ending December 31, 2026.
Market cap
$382M
1Y TSR
-41.9%
Board grade
C
Record date
Apr 13, 2026
Filing
DEF 14A
Meeting concluded · Jun 9, 2026
Follow how the vote landed and what changed on Upstream Bio Inc’s board — director track records, governance grades, and ongoing monitoring — on the Boardroom Alpha platform.
Proposals
On the ballot2
- 1
Election of Class II Directors
ManagementBoard: FORElection of two Class II directors (H. Edward Fleming, Jr., M.D. and Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.) each to serve a three-year term expiring at the 2029 annual meeting, or until their successors are elected and qualified.
- 2
Ratification of Appointment of PricewaterhouseCoopers LLP as Independent Registered Public Accounting Firm for Fiscal Year Ending December 31, 2026
ManagementBoard: FORRatify the audit committee’s appointment of PricewaterhouseCoopers LLP as Upstream Bio’s independent registered public accounting firm for the fiscal year ending December 31, 2026.
Director elections
Nominees on the ballot2
Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.
Independent
Tenure on this board
New nominee
Ownership
Latest 13F quarterTop institutional holders10
| # | Owner | % of shares | Shares | Value |
|---|---|---|---|---|
| 1 | FMR LLC | 13.2% | 7,210,151 | $65M |
| 2 | ORBIMED ADVISORS LLCActivist | 10.5% | 5,693,589 | $51M |
| 3 | Decheng Capital LLC | 5.0% | 2,724,868 | $25M |
| 4 | Enavate Sciences GP, LLC | 4.5% | 2,459,703 | $22M |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 3.4% | 1,873,574 | $17M |
| 6 | BlackRock, Inc. | 2.5% | 1,368,306 | $12M |
| 7 | Y-Intercept (Hong Kong) Ltd | 1.8% | 1,000,631 | $9M |
| 8 | FEDERATED HERMES, INC. | 1.8% | 979,758 | $9M |
| 9 | BlackRock, Inc. | 1.8% | 954,981 | $9M |
| 10 | MILLENNIUM MANAGEMENT LLC | 1.7% | 937,323 | $8M |
Peers
Nearest market capOther Healthcare sector meetings6
Upcoming shareholder meetings at Upstream Bio Inc’s closest sector peers — compare boards, ballots, and ownership across the cohort.
Indaptus Therapeutics IncINDP
Annual meeting·Aug 10, 2026·$287M
Seer IncSEER
Annual meeting·Jul 28, 2026·$119M
Aura Biosciences IncAURA
Special meeting·Aug 5, 2026·$723M
Avanos Medical IncAVNS
Special meeting·Jul 22, 2026·$1.2B
Anaptysbio IncANAB
Annual meeting·Aug 11, 2026·$1.7B
Trulieve Cannabis CorpTRLV
Special meeting·Aug 5, 2026·$1.7B
Reference
Frequently asked questions
- When is the Upstream Bio Inc 2026 annual meeting?
- Upstream Bio Inc (UPB) holds its 2026 annual shareholder meeting on Tuesday, June 9, 2026.
- What is the record date for the Upstream Bio Inc 2026 meeting?
- The record date for the Upstream Bio Inc 2026 meeting is Monday, April 13, 2026. Shareholders of record on or before that date are eligible to vote.
- Who are the director nominees for Upstream Bio Inc's 2026 meeting?
- The board is presenting 2 director nominees at the Upstream Bio Inc 2026 meeting, listed with their independence status and background.
- What proposals will shareholders vote on at the Upstream Bio Inc 2026 meeting?
- Shareholders will vote on 2 proposals at the Upstream Bio Inc 2026 meeting, each tagged with who proposed it and the board's recommendation.
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